Keep in mind that there are already many handmade greetings cards available. To be really successful, you need to offer something a little different. In many areas, the market is swamped with handmade cards. An example of a niche is a "green" handmade card business where all products used are recycled, sustainably sourced, or some portion of proceeds benefit ecology projects around the world. When you are thinking about a niche, a great place to start is to think about the things that inspire you or make you smile. 
Marketing and promoting the business, creating new designs, sourcing products, and administration are the other aspects of running a business that will eat into the time available. You will need to allow for over half your time to be spent on the business side of things. You will also need to think about how you will handle the business if you decide to take a vacation, if you get ill, or managing extremely busy periods. This is why good planning is essential. It will help you avoid any nasty surprises later on.
There is an overwhelming amount of items you can download on this website so it might be a good idea if you have an idea of what you are looking for so you can type it in the search button. I typed in Christmas for my most recent search. There are a ton of botanicals if you want to do a gallery wall of botanicals too…I know that is popular right now)
Never again will partygoers accidentally leave their favors behind when they head home at the end of the night. “This year, brides and grooms are sending guests away with gifts thoughtfully selected to be utilized and enjoyed in their everyday lives,” says Dayna. Because in an age of increasing attention to clutter (thank you, Marie Kondo), functional is the name of the game, and the most popular picks of the moment are the ones designed to be put to use—or even consumed, like these petite, personalized servings of coffee and honey.
In 2014, Etsy garnered a revenue of US$195.6 million, but registered a net loss of US$15.2 million. The platform generates revenue primarily from three streams: its Marketplace revenue includes a fee of [8] 5% of final sale value, which an Etsy seller pays for each completed transaction, on top of a listing fee of 20 cents per item; Seller Services, Etsy's fastest growing revenue stream, includes fees for services such as "Promoted Listings", payment processing, and purchases of shipping labels through the platform; while Other revenue includes fees received from third-party payment processors.[9]

The presentation of the cards—the packaging—helps make a successful handmade card business. A card that is neatly presented in a cellophane envelope looks more professional and can command a higher price than one that is unpackaged. Presenting cards in some form of packaging stops cards from becoming dirty or dog-eared and it also gives the ideal opportunity for further marketing. A label on the back with your phone number or website address could help you solicit further orders. Remember to consider shipping and packaging when factoring the costs per unit in your pricing formula.
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